Water → HCID 22156581, compound

HRID 1073736Notes

Reaction equation

HRID 1073736 reaction equation
C([N:8]1[CH2:12][CH2:11][CH:10]([CH:13]([P:18]([OH:21])(=[O:20])[OH:19])[P:14]([OH:17])(=[O:16])[OH:15])[CH2:9]1)C1C=CC=CC=1.[H][H].[OH2:24]>[Pd]>[OH:24][C:13]([CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1)([P:18]([OH:21])(=[O:20])[OH:19])[P:14]([OH:17])(=[O:16])[OH:15]

Participants

5

Reactant 3

HCID 962WaterHCID 22156599HCID 22156599, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22156581HCID 22156581, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

0.88 g. Ammonium salt of 1-(1-benzylpyrrolidin-3-yl)-methane-1,1-diphosphonic acid (see Example 1 e) is dissolved in 30 ml. water and hydrogenated in the presence of 0.7 g. palladium on charcoal at ambient temperature and normal pressure. After ending of the hydrogen take up, the catalyst is filtered off with suction, the filtrate is evaporated and the residue is treated with acetone. After suction filtration, there is obtained 0.44 g. (65% of theory) of the amorphous ammonium salt x 1 mole water, Mrel : 0.47.

Workup

  1. customat ambient temperature
  2. filtrationthe catalyst is filtered off with suction
  3. customthe filtrate is evaporated
  4. additionthe residue is treated with acetone
  5. filtrationAfter suction filtration
  6. customthere is obtained 0.44 g

Sources & evidence

ORD record
ord-a34fbede8def4126bd748f5a6ba5e9ea
Source dataset
uspto-grants-1990_11
Patent number
US04971958

Reaction notes

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