HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Piperazine, 1-[4,5-bis(trifluoromethyl)-2-pyridinyl]-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-Chloro-4,5-bis(trifluoromethyl)pyridine | HCID 13851612 | — |
| Product | Piperazine, 1-[4,5-bis(trifluoromethyl)-2-pyridinyl]- | HCID 22156760 | 65.2% |
Reaction Steps
Working as described in Example 1, but starting with 10 g (0.04 mol) of 2-chloro-4,5-bis(trifluoromethyl)pyridine and 10.3 g (0.12 mol) of piperazine, the base having a boiling point B.p. 0.04 of 100-102° C. was obtained, and then, after conversion to the hydrochloride, 7.8 g of the title compound .
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04971969 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-c3cc6e9d34d644c5b43208a2f3d2878d |
| Source note | uspto-grants-1990_11 |