Hydrochloric Acid → Piperazine, 1-[4,5-bis(trifluoromethyl)-2-pyridinyl]-

HRID 1073757Notes

Reaction equation

HRID 1073757 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([C:12]([F:15])([F:14])[F:13])=[CH:4][N:3]=1.[NH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.Cl>>[F:9][C:8]([F:11])([F:10])[C:6]1[C:5]([C:12]([F:15])([F:14])[F:13])=[CH:4][N:3]=[C:2]([N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4837PiperazineHCID 138516122-Chloro-4,5-bis(trifluoromethyl)pyridine

Product 1

HCID 22156760Piperazine, 1-[4,5-bis(trifluoromethyl)-2-pyridinyl]-Yield 65.2%

Procedure

Working as described in Example 1, but starting with 10 g (0.04 mol) of 2-chloro-4,5-bis(trifluoromethyl)pyridine and 10.3 g (0.12 mol) of piperazine, the base having a boiling point B.p. 0.04 of 100-102° C. was obtained, and then, after conversion to the hydrochloride, 7.8 g of the title compound .

Workup

  1. custom0.04 of 100-102° C. was obtained

Sources & evidence

ORD record
ord-c3cc6e9d34d644c5b43208a2f3d2878d
Source dataset
uspto-grants-1990_11
Patent number
US04971969

Reaction notes

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