反应详情

A solution of 8.4 g of the thus obtained 7-chloro-2-hexylthio-5H-1,3,4-thiadiazolo[3,2-a]-pyrimidin-5-one and 88.2 g of a 57% hydroiodic acid aqueous solution was heated to 95°~110° C. and stirred for 2 hours. After cooling, the solution was filtered. The residue was washed with water and dissolved in toluene. The toluene solution was washed with a sodium hydrogen carbonate aqueous solution, a sodium thiosulfate aqueous solution and water respectively and dried over anhydrous sodium sulfate. The solvent was distilled off and thus 9.8 g of 80% pure 7-iodo-2-hexylthio-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one was obtained. Yield 72%.

1. temperatureAfter cooling
2. filtrationthe solution was filtered
3. washThe residue was washed with water
4. dissolutiondissolved in toluene
5. washThe toluene solution was washed with a sodium hydrogen carbonate aqueous solution
6. dry with materiala sodium thiosulfate aqueous solution and water respectively and dried over anhydrous sodium sulfate
7. distillationThe solvent was distilled off