反应详情

温度

100 °C

In 100 ml of dimethylformamide, 6 g of 2-hexylthio-7-iodo-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one was dissolved. To this solution, 1.77 g of copper cyanide and 0.97 g of sodium cyanide were added and the solution was stirred at 100° C. for 1 hour. After the reaction mixture was cooled to room temperature, it was extracted with chloroform and water. The organic layer was washed with water and dried over anhydrous sodium sulfate. Florisil® was added to the organic layer and it was shaken. The solvent was distilled off, and 2.3 g of 7-cyano-2-hexylthio-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one was obtained. Yield 51%.

1. temperatureAfter the reaction mixture was cooled to room temperature
2. extractionit was extracted with chloroform and water
3. washThe organic layer was washed with water
4. dry with materialdried over anhydrous sodium sulfate
5. additionFlorisil® was added to the organic layer and it
6. stirringwas shaken
7. distillationThe solvent was distilled off