Dimethylformamide → HCID 178513004, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 980 mg of 1-(2-aminoethyl)-5-mercapto -1H-tetrazole, 696mg of S-methylisourea sulfate, 2.31 ml of triethylamine and 60 ml of DMF was stirred at 70° C. for 17 hours. Then the solvent was distilled off and the residue was purified by a column chromatography (silica gel=150 g; acetonitrile - water=7:1, then 5:1) to give 335mg of 1-(2-guanidinoethyl)-5-mercapto-1H-tetrazole as colorless crystals.

Provenance & Evidence