Dimethylformamide → HCID 178513004, compound

HRID 1073812Notes

Reaction equation

HRID 1073812 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[C:8]([SH:9])=[N:7][N:6]=[N:5]1.C([N:12]([CH2:15]C)CC)C.C[N:18](C=O)C>>[NH:1]([CH2:2][CH2:3][N:4]1[C:8]([SH:9])=[N:7][N:6]=[N:5]1)[C:15]([NH2:12])=[NH:18]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 178511326HCID 178511326, compound

Product 1

HCID 178513004HCID 178513004, compound

Conditions

Temperature
70 °C

Procedure

A mixture of 980 mg of 1-(2-aminoethyl)-5-mercapto -1H-tetrazole, 696mg of S-methylisourea sulfate, 2.31 ml of triethylamine and 60 ml of DMF was stirred at 70° C. for 17 hours. Then the solvent was distilled off and the residue was purified by a column chromatography (silica gel=150 g; acetonitrile - water=7:1, then 5:1) to give 335mg of 1-(2-guanidinoethyl)-5-mercapto-1H-tetrazole as colorless crystals.

Workup

  1. distillationThen the solvent was distilled off
  2. customthe residue was purified by a column chromatography (silica gel=150 g

Sources & evidence

ORD record
ord-1ba257b4773745d0b1ffcad103555c4e
Source dataset
uspto-grants-1990_11
Patent number
US04971963

Reaction notes

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