反应详情

2 g of 3,5-dicarboethoxy-6-methyl-2-(mercaptome-thyl) -4-(m-nitrophenyl)-1,4-dihydropyridine (4,92 mmol.) and 20 mg of 2-sulphosalicylic acid bihydrate (0,049 mmol.) are dissolved in 20 ml of 2,2-dimethoxypropane. The solution is stirred for 2 hours at room temperature, then the solvent is evaporated under reduced pressure. The residue is dissolved in ethyl acetate, washed with a NaHCO3 solution (5%, 2×10 ml) and water (3×20 ml), dried on Na2SO4 and evaporated at reduced pressure. 1.8 g of 3,5-dicarboethoxy-6-methyl-2-[2-methoxyprop-2-yl-thiomethyl]-4-(m-nitrophenyl)-1,4-dihydropyridine (thick yellow oil) are obtained.

1. customthe solvent is evaporated under reduced pressure
2. dissolutionThe residue is dissolved in ethyl acetate
3. washwashed with a NaHCO3 solution (5%, 2×10 ml) and water (3×20 ml)
4. customdried on Na2SO4
5. customevaporated at reduced pressure