反应详情

A solution of 1.84 g (~0.01 mol) of crude 3-formylbenzamidine hydrochloride (prepared analogously to Example 1b) in 10 ml of methanol is added dropwise to a solution of 0.91 g (0.01 mol) of thiosemicarbazide in 5 ml of water and 10 ml of 2N hydrochloric acid. This mixture is heated under reflux for 1 hour, cooled, filtered and concentrated to dryness by evaporation. The residue is recrystallised from methanol; m.p. 210° (with decomposition). The product contains 0.5 mol of water.

1. temperatureThis mixture is heated
2. temperatureunder reflux for 1 hour
3. temperaturecooled
4. filtrationfiltered
5. concentrationconcentrated to dryness by evaporation
6. customThe residue is recrystallised from methanol