Hydrochloric Acid → 125960-58-9

HRID 1073850Notes

Reaction equation

HRID 1073850 reaction equation
FC(F)(F)C([NH:5][CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][C:11]([O:18][CH3:19])=[C:12]([S:14]([NH2:17])(=[O:16])=[O:15])[CH:13]=1)=O.[OH-].[Na+].[ClH:24]>CO>[ClH:24].[NH2:5][CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][C:11]([O:18][CH3:19])=[C:12]([S:14]([NH2:17])(=[O:16])=[O:15])[CH:13]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11427353HCID 11427353, compound

Product 1

HCID 21848695125960-58-9

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 10.0 g of 5-[2-(trifluoroacetylamino)ethyl]-2-methoxybenzenesulfonamide in 100 ml of methanol were added 60 ml of 10% sodium hydroxide aqueous solution with stirring at room temperature and the reaction mixture was stirred for 30 minutes. The reaction mixture was acidfied with 13 ml of hydrochloric acid. The precipitate was filtered and recrystallized from water to give 4.22 g of the desired compound as colorless needles, m.p. 263°-266° C.

Workup

  1. stirringthe reaction mixture was stirred for 30 minutes
  2. filtrationThe precipitate was filtered
  3. customrecrystallized from water

Sources & evidence

ORD record
ord-35e5f50572eb4355a73dfd2f0697db81
Source dataset
uspto-grants-1990_11
Patent number
US04971990

Reaction notes

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