反应详情

A suspension of 10.0 g of N-[2-(5-fluoro-2-methoxyphenoxy)ethyl]phthalimide and 5.14 ml 5.14 ml of hydrazine hydrate in 100 ml of ethanol was heated for 1 hour at 50°-60° C. After cooling, the precipitate was filtered off and the filtrate was evaporated. The residue was diluted with water and extracted with chloroform. The extract was washed with water, dried and evaporated. The residue was distilled to give 3.81 g of the desired compound as a colorless oil, b.p. 126°-127° C. (9 mmHg).

1. temperaturewas heated for 1 hour at 50°-60° C
2. temperatureAfter cooling
3. filtrationthe precipitate was filtered off
4. customthe filtrate was evaporated
5. additionThe residue was diluted with water
6. extractionextracted with chloroform
7. washThe extract was washed with water
8. customdried
9. customevaporated
10. distillationThe residue was distilled