Potassium Bicarbonate → HCID 23715032, compound

HRID 1073987Notes

Reaction equation

HRID 1073987 reaction equation
C([O:5][C:6](=[O:22])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:21])[C@H:13]([CH3:20])[NH:14][S:15]([CH2:18][CH3:19])(=[O:17])=[O:16])(C)(C)C.C(=O)(O)[O-].[K+:27]>Cl.O1CCOCC1>[K+:27].[CH2:18]([S:15]([NH:14][C@H:13]([C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C@H:7]1[C:6]([O-:22])=[O:5])=[O:21])[CH3:20])(=[O:17])=[O:16])[CH3:19]

Participants

5

Reactant 2

HCID 516893Potassium BicarbonateHCID 14858844HCID 14858844, compound

Product 1

HCID 23715032HCID 23715032, compoundYield 79.3%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

N-ethanesulfonyl-L-alanyl-L-proline t-butylester was dissolved in 4.5N hydrochloric acid in dioxane (15 ml) solution and stirred for 3 hours. The solvent was distilled 1 off under reduced pressure and the oily residue thus Obtained (0.72 g) was dissolved in 0.5M aqueous potassium bicarbonate (5.2 ml). The solution was washed with diethyl ether and the water layer was freeze-dried to give N-ethanesulfonyl-L-alanyl-L-proline potassium salt(yield: 0.75 g, 79.3%).

Workup

  1. distillationThe solvent was distilled 1 off under reduced pressure
  2. customthe oily residue thus Obtained (0.72 g)
  3. washThe solution was washed with diethyl ether
  4. dry with materialthe water layer was freeze-dried

Sources & evidence

ORD record
ord-3c66a9286ff543e39c17234255885a64
Source dataset
uspto-grants-1990_11
Patent number
US04971993

Reaction notes

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