HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → glycyl-L-proline benzylester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-Boc-glycyl-L-proline benzyl ester | HCID 13152016 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | glycyl-L-proline benzylester hydrochloride | HCID 13068147 | 88.4% |
Reaction Steps
N-t-butyloxycarbonylglycyl-L-proline benzylester (18.12 g, 50 mmole) was dissolved in 4N hydrochloric acid in dioxane (220 ml) solution, and stirred for 20 minutes at room temperature. The solvent was distilled off and the residue thus obtained was powdered in diethyl ether to obtain glycyl-L-proline benzylester hydrochloride (yield: 13.21 g; 88.4%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04971993 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-beb27e082a4143e5ac489ccc0006a894 |
| Source note | uspto-grants-1990_11 |