Hydrochloric Acid → glycyl-L-proline benzylester hydrochloride

HRID 1073989Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1073989
[CH2:1]([O:8][C:9](=[O:26])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:25])[CH2:16][NH:17]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:27]>O1CCOCC1.C(OCC)C>[ClH:27].[CH2:1]([O:8][C:9](=[O:26])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:25])[CH2:16][NH2:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 13152016N-Boc-glycyl-L-proline benzyl ester

Produkt 1

HCID 13068147glycyl-L-proline benzylester hydrochlorideAusbeute 88,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

N-t-butyloxycarbonylglycyl-L-proline benzylester (18.12 g, 50 mmole) was dissolved in 4N hydrochloric acid in dioxane (220 ml) solution, and stirred for 20 minutes at room temperature. The solvent was distilled off and the residue thus obtained was powdered in diethyl ether to obtain glycyl-L-proline benzylester hydrochloride (yield: 13.21 g; 88.4%).

Aufarbeitung

  1. distillationThe solvent was distilled off
  2. customthe residue thus obtained

Quellen und Nachweise

ORD-Eintrag
ord-beb27e082a4143e5ac489ccc0006a894
Quelldatensatz
uspto-grants-1990_11
Patentnummer
US04971993

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