反应详情

N-t-butyloxycarbonyl-L-prolyl-L-proline benzylester (60.70 g, 150 mmole) was dissolved in 4N hydrochloric acid in dioxane (350 ml) solution, and stirred for 1 hour at room temperature. The solution was concentrated under reduced pressure, and diethyl ether was added to the solution while cooling with ice and stirring to obtain L-prolyl-L-proline benzylester hydrochloride (47.80 g, 94.1%).

1. concentrationThe solution was concentrated under reduced pressure, and diethyl ether
2. additionwas added to the solution
3. temperaturewhile cooling with ice
4. stirringstirring