Hydroxyphenylacetic acid → Ethyl 4-hydroxyphenylacetate

HRID 1074111Notes

Reaction equation

HRID 1074111 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH2:17](O)[CH3:18]>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH2:17][CH3:18])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 127Hydroxyphenylacetic acidHCID 702EthanolHCID 1118Sulfuric Acid

Product 1

HCID 28310Ethyl 4-hydroxyphenylacetate

Procedure

4-Hydroxyphenylacetic acid (50.0 g) is dissolved in ethanol (400 ml) and thereto is added conc. sulfuric acid (0.5 ml). The mixture is refluxed with stirring, and ethanol is distilled off to give ethyl 4-hydroxyphenylacetate (60 g).

Workup

  1. temperatureThe mixture is refluxed
  2. distillationethanol is distilled off

Sources & evidence

ORD record
ord-073b55c0d8b043e582fda565d283ff4a
Source dataset
uspto-grants-1990_11
Patent number
US04973425

Reaction notes

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