HCID 15052487, compound → HCID 15052491, compound

Participants

Reaction Steps

A solution of 2.5 g of tetraethyl [(5-cyclopropyl-3-isoxazolyl)-amino]methylene-bis(phosphonate) in 25 ml of concentrated hydrochloric acid was heated under reflux for 3.5 hours. The reaction mixture was concentrated. Methanol and acetone were added to the concentrate to give 1.7 g of [(5-cyclopropyl-3-isoxazolyl)-amino]-methylene-bis(phosphonic acid) as a solid.

Provenance & Evidence