HCID 15052487, compound → HCID 15052491, compound

HRID 1074133Notes

Reaction equation

HRID 1074133 reaction equation
[CH:1]1([C:4]2[O:8][N:7]=[C:6]([NH:9][CH:10]([P:19](=[O:26])([O:23]CC)[O:20]CC)[P:11](=[O:18])([O:15]CC)[O:12]CC)[CH:5]=2)[CH2:3][CH2:2]1>Cl>[CH:1]1([C:4]2[O:8][N:7]=[C:6]([NH:9][CH:10]([P:11](=[O:12])([OH:18])[OH:15])[P:19](=[O:20])([OH:26])[OH:23])[CH:5]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 1

HCID 15052487HCID 15052487, compound

Product 1

HCID 15052491HCID 15052491, compoundYield 93.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 2.5 g of tetraethyl [(5-cyclopropyl-3-isoxazolyl)-amino]methylene-bis(phosphonate) in 25 ml of concentrated hydrochloric acid was heated under reflux for 3.5 hours. The reaction mixture was concentrated. Methanol and acetone were added to the concentrate to give 1.7 g of [(5-cyclopropyl-3-isoxazolyl)-amino]-methylene-bis(phosphonic acid) as a solid.

Workup

  1. temperatureunder reflux for 3.5 hours
  2. concentrationThe reaction mixture was concentrated
  3. additionMethanol and acetone were added to the
  4. concentrationconcentrate

Sources & evidence

ORD record
ord-42059e2d2a8b424b84124469411a27dd
Source dataset
uspto-grants-1990_11
Patent number
US04973576

Reaction notes

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