HCID 15052502, compound → HCID 15052508, compound

HRID 1074136Notes

Reaction equation

HRID 1074136 reaction equation
[CH2:1]([C:6]1[O:10][N:9]=[C:8]([NH:11][CH:12]([P:21](=[O:28])([O:25]CC)[O:22]CC)[P:13](=[O:20])([O:17]CC)[O:14]CC)[CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5]>Cl>[CH2:1]([C:6]1[O:10][N:9]=[C:8]([NH:11][CH:12]([P:21](=[O:22])([OH:28])[OH:25])[P:13](=[O:14])([OH:20])[OH:17])[CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

3

Reactant 1

HCID 15052502HCID 15052502, compound

Product 1

HCID 15052508HCID 15052508, compoundYield 80.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 3 g of tetraethyl [(5-n-pentyl-3-isoxazolyl)amino]methylene-bis(phosphonate) in 30 ml of concentrated hydrochloric acid was heated under reflux for 3 hours. After the reaction mixture was concentrated, the solid obtained was washed with acetonitrile to give 1.8 g of [(5-n-pentyl-3-isoxazolyl)amino]methylene-bis(phosphonic acid) as a solid.

Workup

  1. temperatureunder reflux for 3 hours
  2. concentrationAfter the reaction mixture was concentrated
  3. customthe solid obtained
  4. washwas washed with acetonitrile

Sources & evidence

ORD record
ord-d799188b1f894acb9c2fc9c7de6699d5
Source dataset
uspto-grants-1990_11
Patent number
US04973576

Reaction notes

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