HCID 15052515, compound → HCID 15052516, compound

HRID 1074137Notes

Reaction equation

HRID 1074137 reaction equation
[CH2:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][CH:11]([P:20](=[O:27])([O:24]CC)[O:21]CC)[P:12](=[O:19])([O:16]CC)[O:13]CC)[CH:6]=1)[CH2:2][CH2:3][CH3:4]>Cl>[CH2:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][CH:11]([P:20](=[O:21])([OH:27])[OH:24])[P:12](=[O:13])([OH:16])[OH:19])[CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 15052515HCID 15052515, compound

Product 1

HCID 15052516HCID 15052516, compoundYield 70.7%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 4.8 g of tetraethyl [(5-n-butyl-3-isoxazolyl)amino]methylene-bis(phosphonate) in 50 ml of concentrated hydrochloric acid was heated under reflux for 3 hours. After the reaction mixture was concentrated, the solid obtained was washed with acetonitrile to give 2.5 g of [(5-n-butyl-3-isoxazolyl)amino]methylene-bis(phosphonic acid) as a solid.

Workup

  1. temperatureunder reflux for 3 hours
  2. concentrationAfter the reaction mixture was concentrated
  3. customthe solid obtained
  4. washwas washed with acetonitrile

Sources & evidence

ORD record
ord-b44f9a8cf0ae4d4fb3bd33cd346e4081
Source dataset
uspto-grants-1990_11
Patent number
US04973576

Reaction notes

Loading…