HCID 15052495, compound → HCID 15052526, compound

HRID 1074139Notes

Reaction equation

HRID 1074139 reaction equation
[CH2:1]([C:3]1[O:7][N:6]=[C:5]([NH:8][CH:9]([P:18](=[O:25])([O:22]CC)[O:19]CC)[P:10](=[O:17])([O:14]CC)[O:11]CC)[CH:4]=1)[CH3:2]>Cl>[CH2:1]([C:3]1[O:7][N:6]=[C:5]([NH:8][CH:9]([P:18](=[O:19])([OH:25])[OH:22])[P:10](=[O:11])([OH:17])[OH:14])[CH:4]=1)[CH3:2]

Participants

3

Reactant 1

HCID 15052495HCID 15052495, compound

Product 1

HCID 15052526HCID 15052526, compoundYield 79.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 4.9 g of tetraethyl [(5-ethyl-3-isoxazolyl)amino]methylene-bis(phosphonate) in 46 ml of concentrated hydrochloric acid was heated under reflux for 3 hours. After the reaction mixture was concentrated, the solid obtained was washed with acetone to give 2.8 g of [(5-ethyl-3-isoxazolyl)amino]methylene-bis(phosphonic acid) as a solid.

Workup

  1. temperatureunder reflux for 3 hours
  2. concentrationAfter the reaction mixture was concentrated
  3. customthe solid obtained
  4. washwas washed with acetone

Sources & evidence

ORD record
ord-3543faacff154c03814d2c363d767786
Source dataset
uspto-grants-1990_11
Patent number
US04973576

Reaction notes

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