HCID 15052522, compound → HCID 15052527, compound

HRID 1074140Notes

Reaction equation

HRID 1074140 reaction equation
[CH3:1][C:2]1[C:3]([NH:7][CH:8]([P:17](=[O:24])([O:21]CC)[O:18]CC)[P:9](=[O:16])([O:13]CC)[O:10]CC)=[N:4][O:5][CH:6]=1>Cl>[CH3:1][C:2]1[C:3]([NH:7][CH:8]([P:17](=[O:18])([OH:24])[OH:21])[P:9](=[O:10])([OH:13])[OH:16])=[N:4][O:5][CH:6]=1

Participants

3

Reactant 1

HCID 15052522HCID 15052522, compound

Product 1

HCID 15052527HCID 15052527, compoundYield 79.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 3.2 g of tetraethyl [(4-methyl-3-isoxazolyl)amino]methylene-bis(phosphonate) in 32 ml of concentrated hydrochloric acid was heated under reflux for 4 hours. After the reaction mixture was concentrated, the solid obtained was washed with a mixture of methanol-acetonitrile-acetone to give 1.8 g of [(4-methyl-3-isoxazolyl)amino]methylene-bis(phosphonic acid) as a solid.

Workup

  1. temperatureunder reflux for 4 hours
  2. concentrationAfter the reaction mixture was concentrated
  3. customthe solid obtained
  4. washwas washed with a mixture of methanol-acetonitrile-acetone

Sources & evidence

ORD record
ord-8d9a4f05d4b945d6802863bdb9e7d632
Source dataset
uspto-grants-1990_11
Patent number
US04973576

Reaction notes

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