Methylamine → HCID 22155942, compound

HRID 1074148Notes

Reaction equation

HRID 1074148 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([NH:10][C:11]2[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:18])=[O:9])=[CH:4][CH:3]=1.[CH3:19][NH2:20]>C(O)C>[CH3:19][NH:20][C:2]1[N:7]=[CH:6][C:5]([C:8]([NH:10][C:11]2[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:18])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 18419454HCID 18419454, compound

Product 1

HCID 22155942HCID 22155942, compoundYield 57.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5 g of 6-chloro-N-(2,6-dimethylphenyl)-3-pyridinecarboxamide and 6 g of methylamine (from a 40% aqueous solution) in 100 ml of ethanol were heated at 250° C. in a closed reaction vessel for 72 hours. The reaction mixture was cooled to room temperature, solvents were removed under reduced pressure, and the product was recrystallized from ethanol, providing 2.8 g of the desired title product, m.p. 207°-209° C.

Workup

  1. customsolvents were removed under reduced pressure
  2. customthe product was recrystallized from ethanol

Sources & evidence

ORD record
ord-0f7930ec28554c47afc77ccb406e25aa
Source dataset
uspto-grants-1990_11
Patent number
US04973597

Reaction notes

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