反应详情

温度

140 °C

A mixture of 1-phenyl-1-cyclohexyl-3-chloro-1-propanol (3.8 g) and sodium cyanide (0.69 g) in 11 ml of dimethyl sulphoxide (DMSO) was heated at 140° C. for 3 hours. The mixture was poured into ice, then the water was extracted with ether. The solvent was removed and the residue triturated with diisopropylic ether to afford 2.7 g of 1-phenyl-1-cyclohexyl-3-cyano-1-propanol. M.p. 97°-101° C.

1. additionThe mixture was poured into ice
2. extractionthe water was extracted with ether
3. customThe solvent was removed
4. customthe residue triturated with diisopropylic ether