HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1074149Generated: October 25, 2026
Sodium Cyanide → 1-Phenyl-1-cyclohexyl-3-cyano-1-propanol
https://huagongshe.com/reaction/1074149
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 1-Phenyl-1-cyclohexyl-3-chloro-1-propanol | HCID 13841196 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 1-Phenyl-1-cyclohexyl-3-cyano-1-propanol | HCID 22155872 | 78.8% |
Reaction Steps
A mixture of 1-phenyl-1-cyclohexyl-3-chloro-1-propanol (3.8 g) and sodium cyanide (0.69 g) in 11 ml of dimethyl sulphoxide (DMSO) was heated at 140° C. for 3 hours. The mixture was poured into ice, then the water was extracted with ether. The solvent was removed and the residue triturated with diisopropylic ether to afford 2.7 g of 1-phenyl-1-cyclohexyl-3-cyano-1-propanol. M.p. 97°-101° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04973592 |
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| Source dataset | uspto-grants-1990_11 |
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| ORD ID | ord-8c8207ee99334e31a346fd532bb00ef3 |
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| Source note | uspto-grants-1990_11 |
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