反应详情

A 25 ml egg-plant type flask was flushed with argon, and 42.4 mg (0.45 mmol) of phenol, 2 ml of dry 1,1,2-trichloroethane and 95.3 mg (0.45 mmol) of N-fluoro-2-chloropyridinium-6-sulfonate were charged. The flask was immersed in an oil bath of 100° C. and heated for 49 hours. After completion of the reaction, the reaction solution was washed with water to remove 2-chloropyridine-6-sulfonic acid. The organic layer was quantitatively analyzed by gas chromatography. o-Fluorophenol was obtained at a conversion yield of 58%, and phenol was recovered at a recovery rate of 5%.

1. additionwere charged
2. customThe flask was immersed in an oil bath of 100° C.
3. temperatureheated for 49 hours
4. customAfter completion of the reaction
5. washthe reaction solution was washed with water
6. customto remove 2-chloropyridine-6-sulfonic acid