Methylamine → 2,4-Dibromo-N-methylbutanamide

HRID 1074237Notes

Reaction equation

C[O:2][C:3](=O)[CH:4]([Br:8])[CH2:5][CH2:6][Br:7].[CH3:10][NH2:11]>>[CH3:10][NH:11][C:3](=[O:2])[CH:4]([Br:8])[CH2:5][CH2:6][Br:7]

Participants

Reactant 2

HCID 6329Methylamine

HCID 296716Methyl 2,4-dibromobutanoate

Product 1

HCID 150679832,4-Dibromo-N-methylbutanamide

Procedure

In a second step of the reaction, the methyl-2,4-dibromobutyrate is reacted with methylamine in an aqueous solution at a temperature of below ambient in order to form N-methyl-2,4-dibromobutyramide. Then butyramide is then recovered and purified to obtain the solid intermediate product.

Workup

customIn a second step of the reaction

Sources & evidence

ORD record: ord-74d84d546d114887a92222d2404c8457
Source dataset: uspto-grants-1990_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04973708

Reaction notes

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