4-Hydroxybenzoic Acid → Benzyl 4-Hydroxybenzoate

Participants

Reaction Conditions

Reaction Steps

69.1 g (0.5 mole) of p-hydroxybenzoic acid, 216.2 g (2 moles) of benzyl alcohol, 0.7 g of tetraisopropyl titanate and 30 g of xylene were fed into a fournecked glass flask, and refluxed for 3 hours with stirring in an atmosphere of nitrogen. During this time, the temperature of the reaction mixture was maintained at 85° C. Water formed by the reaction was removed out of the reaction system by the Dien-Stark's device. The presence of xylene simplified temperature control and promoted removal of water. Benzyl p-hydroxybenzoate was obtained in a yield of 98.7%.

Provenance & Evidence