Mesityl oxide → HCID 131716720, compound

HRID 1074309Notes

Reaction equation

[CH3:1][CH2:2]/[C:3](/[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)=[C:4](/[C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])=[CH:16][CH:17]=1)\[C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1.[O:30]=[C:31]([CH:33]=[C:34]([CH3:36])[CH3:35])[CH3:32]>>[CH3:1][CH2:2]/[C:3](/[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)=[C:4](/[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])=[CH:14][CH:13]=1)\[C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[O:30]=[C:31]([CH:33]=[C:34]([CH3:36])[CH3:35])[CH3:32]

Participants

Reactant 2

HCID 8858Mesityl oxide

HCID 4494594-Hydroxytamoxifen

Product 1

HCID 131716720HCID 131716720, compound

Conditions

Temperature: 15 °C

Procedure

0.1 mol of the 4-hydroxytamoxifen complexes from Examples (1c2) and 2 are introduced into 400 ml of mesityl oxide at 60° C. When the substance has dissolved, the solution is cooled to 15° C. and the precipitate obtained is suction filtered and washed with 75 ml of methyl tert.-butyl ether.

Workup

dissolutionWhen the substance has dissolved
customthe precipitate obtained
filtrationfiltered
washwashed with 75 ml of methyl tert.-butyl ether

Sources & evidence

ORD record: ord-e1cd44ffe13e4808b9031a637015b75a
Source dataset: uspto-grants-1990_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04973755

Reaction notes

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