反应详情

A mixture of 2-cyclopropyloxyimino-2-(2-formamidothiazol-4-yl) acetic acid (syn isomer) (255 mg) and conc. hydrochloric acid (0.21 ml) in methanol (1.3 ml) was stirred at 30° to 32° C. for 1.5 hours. The mixture was concentrated in vacuo, triturated with diisopropyl ether, diethyl ether and ethyl acetate in turn. The resultant solid was dried over phosphorus pentoxide to give 2-(2-aminothiazol-4-yl)-2-cyclopropyloxyiminoacetic acid hydrochloride (syn isomer) (265 mg).

1. concentrationThe mixture was concentrated in vacuo
2. customtriturated with diisopropyl ether, diethyl ether and ethyl acetate in turn
3. dry with materialThe resultant solid was dried over phosphorus pentoxide