反应详情

A solution of 6 g of 3-tert-butylaminosulfonylbenzothiophene-2-carboxylate acid in 100 ml of methanol was saturated with anhydrous hydrogen chloride and then heated to reflux for three hours. The mixture was evaporated in vacuo to half of its volume and the residue poured into 200 g of ice and filtered to yield the desired product melting at 150°-154°. The infrared absorption spectrum shown by this material was qualitatively equivalent to that of the product of Example 4.

1. temperatureheated
2. temperatureto reflux for three hours
3. customThe mixture was evaporated in vacuo to half of its volume
4. additionthe residue poured into 200 g of ice
5. filtrationfiltered