Pyrrolidine → HCID 13175259, compound

HRID 1074387Notes

Reaction equation

HRID 1074387 reaction equation
Cl[C:2]1[CH:14]=[CH:13][C:5]2=[N:6][C:7]3[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=3[N:4]2[N:3]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[CH:14]=[CH:13][C:5]3=[N:6][C:7]4[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=4[N:4]3[N:3]=2)[CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 11148455HCID 11148455, compound

Product 1

HCID 13175259HCID 13175259, compound

Procedure

A mixture was prepared from 5.0 g of 2-chloro-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole and 30 ml of pyrrolidine and this was stirred and heated at reflux for 18 hours. The reaction mixture was then poured into 200 ml of ice water. A solid formed and this was separated by filtration and recrystallized from a mixture of ethanol and water to give 2-(1-pyrrolidinyl)-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole melting at about 161° C. This compound has the following structure formula ##STR2##

Workup

  1. temperatureheated
  2. temperatureat reflux for 18 hours
  3. customA solid formed
  4. customthis was separated by filtration
  5. customrecrystallized from a mixture of ethanol and water

Sources & evidence

ORD record
ord-9579fc25dc844779afc35826f46a1abe
Source dataset
uspto-grants-1983_07
Patent number
US04391806

Reaction notes

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