Piperidine → HCID 20496598, compound

HRID 1074389Notes

Reaction equation

HRID 1074389 reaction equation
Cl[C:2]1[CH:14]=[CH:13][C:5]2=[N:6][C:7]3[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=3[N:4]2[N:3]=1.[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[CH:14]=[CH:13][C:5]3=[N:6][C:7]4[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=4[N:4]3[N:3]=2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 11148455HCID 11148455, compound

Product 1

HCID 20496598HCID 20496598, compound

Procedure

A solution of 5.0 g of 2-chloro-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole in 30 ml of piperidine was stirred and heated at reflux for 72 hours. The reaction mixture was poured into 200 ml of ice water and the tan solid which formed was separated by filtration and air dried. It was then recrystallized from a mixture of ethanol and water to give 2-(1-piperidinyl)-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole melting at about 184°-185° C.

Workup

  1. temperatureheated
  2. temperatureat reflux for 72 hours
  3. customthe tan solid which formed
  4. customwas separated by filtration and air
  5. customdried
  6. customIt was then recrystallized from a mixture of ethanol and water

Sources & evidence

ORD record
ord-85e88e01e10f4ea59afe1e3eb82b2c5d
Source dataset
uspto-grants-1983_07
Patent number
US04391806

Reaction notes

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