Pyrrolidine → 6-(1-Pyrrolidinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

HRID 1074391Notes

Reaction equation

HRID 1074391 reaction equation
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][CH:13]=[CH:14][N:4]2[N:3]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[C:5]3=[N:12][CH:13]=[CH:14][N:4]3[N:3]=2)[CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 131789756-Chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

Product 1

HCID 131789766-(1-Pyrrolidinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

Procedure

A mixture was prepared by adding 4.5 g of 6-chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine to 8.7 g of pyrrolidine and this was heated at reflux for 6.5 hours during which time the mixture turned brown. The reaction mixture was then poured into about 150 ml of ice water. A solid formed immediately and this was separated by filtration and air dried to give 6-(1-pyrrolidinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine melting at about 128° C.

Workup

  1. customA mixture was prepared
  2. temperaturethis was heated
  3. temperatureat reflux for 6.5 hours during which time the mixture
  4. customA solid formed immediately
  5. customthis was separated by filtration and air
  6. customdried

Sources & evidence

ORD record
ord-3d058b71237d4773ac9fe46eeb6fab86
Source dataset
uspto-grants-1983_07
Patent number
US04391807

Reaction notes

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