1-Methylpiperazine → 6-(4-Methyl-1-piperazinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

HRID 1074393Notes

Reaction equation

HRID 1074393 reaction equation
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][CH:13]=[CH:14][N:4]2[N:3]=1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:2]2[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[C:5]3=[N:12][CH:13]=[CH:14][N:4]3[N:3]=2)[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 131789756-Chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

Product 1

HCID 131789786-(4-Methyl-1-piperazinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

Procedure

A mixture of 15 g of 6-chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine and 36.2 g of 1-methylpiperazine was heated at reflux for 48 hours during which time the reaction mixture turned brown. The reaction was poured into about 150 ml of ice water. The solid which formed was separated by filtration and air-dried to give 6-(4-methyl-1-piperazinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine melting at about 79.5° C.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 48 hours during which time the reaction mixture
  3. customThe solid which formed
  4. customwas separated by filtration
  5. customair-dried

Sources & evidence

ORD record
ord-8d2f3a9a111541c88a29b7a49eca0cdd
Source dataset
uspto-grants-1983_07
Patent number
US04391807

Reaction notes

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