反应详情

17 g 7-hydroxy-3-phenyl-3,4-dihydro-2H-1-benzopyrane, 0.1 cm3 piperidine and 100 cm3 1-chloro-2,3-epoxypropane were stirred for 6 hours at a temperature of 90° C. The solution was evaporated under reduced pressure, the residue was dissolved in 150 cm3 benzene and the obtained solution was extracted twice with 25--25 cm3 saturated sodium carbonate solution. The benzene phase was separated from the precipitated resin, clarificated with charcoal, filtered and evaporated. Crystallizing the residue from methanol, 15 g pure crystalline 1,2-epoxy-3-(3-phenyl-3,4-dihydro-2H-1-benzopyrane-7-yloxy)-propane was obtained (m.p. 117°-119° C.).

1. customThe solution was evaporated under reduced pressure
2. dissolutionthe residue was dissolved in 150 cm3 benzene
3. extractionthe obtained solution was extracted twice with 25--25 cm3 saturated sodium carbonate solution
4. customThe benzene phase was separated from the precipitated resin
5. filtrationfiltered
6. customevaporated
7. customCrystallizing the residue from methanol