2-Phenylchroman-7-ol → 1-chloro-4-(2-phenyl-3,4-dihydro-2H-1-benzopyrane-7-yloxy)-2-butanol

HRID 1074463Notes

Reaction equation

HRID 1074463 reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][C:10]3[CH:13]=[CH:14][C:15]([OH:17])=[CH:16][C:9]=3[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:18][CH:19](O)[CH2:20][CH2:21][CH2:22]Cl.ClCCC1[O:30]C1>>[Cl:18][CH2:19][CH:20]([OH:30])[CH2:21][CH2:22][O:17][C:15]1[CH:14]=[CH:13][C:10]2[CH2:11][CH2:12][CH:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[O:8][C:9]=2[CH:16]=1

Participants

4

Reactant 3

HCID 35126382-Phenylchroman-7-olHCID 125197222-(2-Chloroethyl)oxiraneHCID 193475421,4-Dichlorobutanol

Product 1

HCID 204967261-chloro-4-(2-phenyl-3,4-dihydro-2H-1-benzopyrane-7-yloxy)-2-butanol

Procedure

The starting 1-chloro-4-(2-phenyl-3,4-dihydro-2H-1-benzopyrane-7-yloxy)-2-butanol was prepared from 2-phenyl-7-hydroxy-3,4-dihydro-2H-1-benzopyrane (J.Chem. Soc., 3137; 1954) and 1,4-dichlorobutanol according to example 1 (b), or from 1-phenyl-7-hydroxy-3,4-dihydro-2H-1-benzopyrane and 1-chloro-3,4-epoxybutane according to example 1 (c).

Sources & evidence

ORD record
ord-7f9fa53fa3704fbd8de4029cd2308cd3
Source dataset
uspto-grants-1983_07
Patent number
US04391821

Reaction notes

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