1,4-Dioxane → 2-(3-Chloro-4-bromobenzyl)-1,2-dihydro-1-oxophthalazin-4-ylacetic acid
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Br:11])[CH2:5][NH:6][NH2:7].[C:12](=[O:15])([O-])[OH:13].[Na+].[O:17]1[CH2:22][CH2:21]OCC1>O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Br:11])[CH2:5][N:6]1[N:7]=[C:9]([CH2:8][C:12]([OH:13])=[O:15])[C:10]2[C:21](=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:22]1=[O:17]Participants
Procedure
3-Chloro-4-bromobenzylhydrazine (2.5 g.) was added to a stirred mixture of 3-oxo-Δ1,α-phthalanacetic acid (also known as phthalideneacetic acid (1.92 g.) and sodium hydrogen carbonate (2.0 g.) in dioxan (50 ml.) and water (25 ml.). The mixture was then heated under reflux for 3 hours, cooled to room temperature and poured into water (200 ml.). The aqueous solution was extracted with ether (3×100 ml.) and the aqueous phase was acidified with concentrated hydrochloric acid to pH 2. The solid which deposited was collected, washed well with water, dried in vacuo, and then recrystallised twice from a mixture of toluene isopropanol and petrol (60-80) (6:2:3 v/v/v) to give 2-(3-chloro-4-bromobenzyl)-1,2-dihydro-1-oxophthalazin-4-ylacetic acid (0.23 g.), m.p. 184°-186° C.
Workup
- temperatureThe mixture was then heated
- temperatureunder reflux for 3 hours
- extractionThe aqueous solution was extracted with ether (3×100 ml.)
- customThe solid which deposited was collected
- washwashed well with water
- customdried in vacuo
- customrecrystallised twice from a mixture of toluene isopropanol and petrol (60-80) (6:2:3 v/v/v)
Sources & evidence
- ORD record
- ord-ed0024e3187c40f696a5c640eeae2b7a
- Source dataset
- uspto-grants-1983_07
- Patent number
- US04393062
Reaction notes
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