HCID 20496156, compound → HCID 20496154, compound

HRID 1074586Notes

Reaction equation

HRID 1074586 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[C:5]([N+:13]([O-])=O)[CH:4]=1>[Pd]>[NH2:13][C:5]1[CH:4]=[C:3]([NH:2][CH3:1])[CH:8]=[CH:7][C:6]=1[C:9]([F:11])([F:12])[F:10]

Participants

3

Reactant 1

HCID 20496156HCID 20496156, compound

Product 1

HCID 20496154HCID 20496154, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of N-methyl-3-nitro-4-trifluoromethylbenzenamine (20 g., 0.09 mole) and absolute alcohol (200 ml.) was reduced with 5% palladium on carbon 50% wet. The material absorbed 24 lbs. of hydrogen (100% theory) in 1 hr. The catalyst was removed by filtration and the filtrate stripped in vacuo. The dark oil crystallized to give 17 g. (99%). The material used as an intermediate in Part C.

Workup

  1. customThe material absorbed 24 lbs
  2. customThe catalyst was removed by filtration
  3. customThe dark oil crystallized
  4. customto give 17 g

Sources & evidence

ORD record
ord-decf1adc2d3e4f5b8e64c6172cc1b294
Source dataset
uspto-grants-1983_07
Patent number
US04393208

Reaction notes

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