Dimethylformamide dimethyl acetal → HCID 70535927, compound

HRID 1074599Notes

Reaction equation

HRID 1074599 reaction equation
[C:1]([CH2:3][C:4]([NH:6][C:7]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:8]=1[F:14])=[O:5])#[N:2].CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>>[C:1]([C:3](=[CH:17][N:18]([CH3:20])[CH3:19])[C:4]([NH:6][C:7]1[C:8]([F:14])=[CH:9][CH:10]=[CH:11][C:12]=1[F:13])=[O:5])#[N:2]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 13174846HCID 13174846, compound

Product 1

HCID 70535927HCID 70535927, compound

Procedure

As for Example 1, 2-cyano-2',6'-difluoroacetanilide as colorless crystals, m.p. 180°-181° C. (prepared by the procedure described in U.S. Pat. No. 3,116,312), is heated with N,N-dimethylformamide dimethylacetal to yield 2-cyano-3-dimethylamino-2', 6'-difluoroacrylanilide as colorless crystals, m.p. 158°-159.5° C.

Sources & evidence

ORD record
ord-cd24864a6f89468d988b732ad8e85bbe
Source dataset
uspto-grants-1983_07
Patent number
US04393217

Reaction notes

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