Dimethylformamide dimethyl acetal → 2-Cyano-N-(2,5-difluorophenyl)-3-(dimethylamino)-2-propenamide

HRID 1074600Notes

Reaction equation

HRID 1074600 reaction equation
[C:1]([CH2:3][C:4]([NH:6][C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[F:14])=[O:5])#[N:2].CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>>[C:1]([C:3](=[CH:17][N:18]([CH3:20])[CH3:19])[C:4]([NH:6][C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[F:14])=[O:5])#[N:2]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 13174847HCID 13174847, compound

Product 1

HCID 544787042-Cyano-N-(2,5-difluorophenyl)-3-(dimethylamino)-2-propenamide

Procedure

As for Example 1, 2-cyano-2',5'-difluoroacetanilide, colorless crystals, m.p. 165°-167° C. (prepared by the procedure described in U.S. Pat. No. 3,116,312), is heated with N,N-dimethylformamide dimethylacetal to give 2-cyano-3-dimethylamino-2',5'-difluoroacrylanilide as colorless needles, m.p. 175°-176° C.

Sources & evidence

ORD record
ord-8a485297efbb4438a1749904943f922f
Source dataset
uspto-grants-1983_07
Patent number
US04393217

Reaction notes

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