反应详情

Then, 10.4 g of 2-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone was dissolved in 80 ml of ethyl acetate and 4 g of maleic acid was added to the solution, followed by stirring while warming. After cooling, the precipitated crystals were filtered and recrystallized from a mixture of diethyl ether and petroleum ether to obtain 12.2 g of 2-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone maleate having a melting point of 160.5° C. as colorless prisms.

1. temperaturewhile warming
2. temperatureAfter cooling
3. filtrationthe precipitated crystals were filtered
4. customrecrystallized from a mixture of diethyl ether and petroleum ether