Hydrogen Bromide → 2-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone hydrobromide

HRID 1074619Notes

Reaction equation

HRID 1074619 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH:19]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]2=[O:26])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[BrH:27]>CC(C)=O>[BrH:27].[N:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH:19]=[C:18]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]2=[O:26])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 131747412-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone

Product 1

HCID 204961762-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone hydrobromide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

10.4 g of 2-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone was dissolved in 50 ml of acetone and 10 ml of a 47% aqueous solution of hydrobromic acid was added thereto and the mixture was warmed. After cooling, the precipitated crystals were filtered and recrystallized from a mixture of methanol and petroleum ether to obtain 11.6 g of 2-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone hydrobromide having a melting point of 300° C. as colorless needles.

Workup

  1. temperaturethe mixture was warmed
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were filtered
  4. customrecrystallized from a mixture of methanol and petroleum ether

Sources & evidence

ORD record
ord-223778dc61644cefab979ce2233bba35
Source dataset
uspto-grants-1983_07
Patent number
US04393210

Reaction notes

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