反应详情

10.4 g of 2-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone was dissolved in 50 ml of acetone and 10 ml of a 47% aqueous solution of hydrobromic acid was added thereto and the mixture was warmed. After cooling, the precipitated crystals were filtered and recrystallized from a mixture of methanol and petroleum ether to obtain 11.6 g of 2-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone hydrobromide having a melting point of 300° C. as colorless needles.

1. temperaturethe mixture was warmed
2. temperatureAfter cooling
3. filtrationthe precipitated crystals were filtered
4. customrecrystallized from a mixture of methanol and petroleum ether