Oxalyl chloride → HCID 86738950, compound

To a solution of 1.98 g of ethyl potassium epoxysuccinate (i.e. ethyl potassium oxirane 2,3-dicarboxylate) in 50 ml of ethyl ether, a solution of 1.4 g of oxalyl chloride in 30 ml of ethyl ether was added dropwise while being stirred and cooled by ice for 30 min. After the mixture had been stirred additionally at room temperature for 2 hours, the formed precipitate was filtered. The filtrate was concentrated by evaporation under reduced pressure to give epoxysuccinic acid monoethyl ester chloride as an oil. Then, the acid chloride was dissolved in 30 ml of ethyl ether and the solution thus obtained was added dropwise to a solution of 1.6 g of L-leucine ethyl ester and 1.1 g of triethylamine dissolved in 50 ml of ethyl ether while being stirred and cooled by ice for 30 min. After the mixture had been stirred additionally at room temperature for three hours, the formed precipitate was filtered. The filtrate was evaporated under reduced pressure to give an oil. The oil thus obtained was further purified by silica gel column chromatography using chloroform-acetone (100:5) mixture as solvent to give N-(3-ethoxycarbonyloxirane-2-carbonyl)-L-leucine ethyl ester(EP-146) as a colorless oil. Yield 1.9 g (63%). Mass: m/e 301 (M+). IRνfilm (cm-1): 3370 (amine), 1748 (ester), 1680, 1545 (amide), 895 (epoxide). NMR(CDCl3)δ: 0.95 (6H, d, J=5 Hz), 1.26 (3H, t, J=7 Hz), 1.29 (3H, t, J=7 Hz), 1.64 (3H, m), 3.42 (0.5 H, d, J=2 Hz), 3.51 (0.5 H, d, J=2 Hz), 3.67 (1H, d, J=2 Hz), 4.20 (4H, q, J=2 Hz), 4.6 (1H, m), 6.35 (1H, b.).

1. temperaturecooled by ice for 30 min
2. stirringAfter the mixture had been stirred additionally at room temperature for 2 hours
3. filtrationthe formed precipitate was filtered
4. concentrationThe filtrate was concentrated by evaporation under reduced pressure

ORD record

ord-40922560d6fa49f1953d2a3c8d931f01

Source dataset

uspto-grants-1983_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04393228