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HRID1074862

反应详情

EQUATION

反应方程式

HRID 1074862 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：Cc1cc(C)c([N+](=O)[O-])cc1N
HCID228007

2,4-Dimethyl-5-nitroaniline

C8H10N2O2

结构：Cc1ccc(S(=O)(=O)O)cc1.O
HCID521998

4-Methylbenzenesulfonic acid hydrate

C7H10O4S

结构：COC(=O)c1c(C)occ(Cl)c1=O
HCID20494972

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1c(C)n(-c2cc([N+](=O)[O-])c(C)cc2C)cc(Cl)c1=O
HCID20494956

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A solution of 10.1 g (0.05 mol) 5-chloro-3-methoxycarbonyl-2-methyl-4-pyranone, 8.5 g 2,4-dimethyl-5-nitroaniline and 0.1 g p-toluenesulfonic acid monohydrate in 100 ml of toluene are refluxed for 8 h in a water separator apparatus. The mixture is allowed to cool and the precipitating product is filtered off, washed with a small amount of ethylacetate/petrolether and dried. Yield: 15.0 g (85.5%) 1-(3'-nitro-4',6'-dimethylphenyl)-5-chloro-3-methoxycarbonyl-2-methyl-4-pyridone, mp. 266° C.

WORKUP

后处理

  1. temperatureto cool
  2. filtrationthe precipitating product is filtered off
  3. washwashed with a small amount of ethylacetate/petrolether
  4. customdried