反应详情

温度

0 °C

Dropwise 13 ml (0.17 mole) of methanesulfonyl chloride was added to a solution of 28.9 g (0.1 mole) of 3-hydroxy-1-[4-chloro-2-(2-fluorobenzoyl)phenyl]propyne and 24.4 ml (0.175 mole) of triethylamine in 300 ml of methylene chloride which was cooled to 0° C. The mixture was washed with ice water, cold 1 N hydrochloric acid, cold saturated aqueous sodium bicarbonate and dried over anhydrous sodium sulfate. Concentration of the methylene chloride solution gave a brown oil which was crystallized from ether to give a yellow solid. Recrystallization from a mixture of ether and petroleum ether gave off-white prisms, mp 95°-96° C.

1. washThe mixture was washed with ice water, cold 1 N hydrochloric acid, cold saturated aqueous sodium bicarbonate
2. dry with materialdried over anhydrous sodium sulfate
3. customConcentration of the methylene chloride solution gave a brown oil which
4. customwas crystallized from ether
5. customto give a yellow solid
6. customRecrystallization
7. additionfrom a mixture of ether and petroleum ether
8. customgave off-white prisms, mp 95°-96° C.