Ethylenediaminetetraacetic Acid → Edetate Sodium

HRID 1074884Notes

Reaction equation

HRID 1074884 reaction equation
[CH2:1]([N:12]([CH2:17][C:18]([OH:20])=[O:19])[CH2:13][C:14]([OH:16])=[O:15])[CH2:2][N:3]([CH2:8][C:9]([OH:11])=[O:10])[CH2:4][C:5]([OH:7])=[O:6].[OH-].[Na+:22].[Na]>O>[CH2:2]([N:3]([CH2:8][C:9]([O-:11])=[O:10])[CH2:4][C:5]([O-:7])=[O:6])[CH2:1][N:12]([CH2:17][C:18]([O-:20])=[O:19])[CH2:13][C:14]([O-:16])=[O:15].[Na+:22].[Na+:22].[Na+:22].[Na+:22]

Participants

5

Reactant 3

HCID 6049Ethylenediaminetetraacetic AcidHCID 14798Sodium HydroxideHCID 5360545Sodium

Product 1

HCID 6144Edetate Sodium

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of tetrasodium ethylenediaminetetraacetate was prepared by mixing 8.0033 grams of solid ethylenediaminetetraacetic acid with 250 ml H2O and about 10.5 grams of a 50% aqueous solution of sodium hydroxide. This mixture includes sufficient sodium to provide a pH at least 12 (actual pH was 13.1) in the resulting solution of sodium EDTA. A large excess of caustic was avoided, because excess caustic will, in the next step of the process, react with cobalt to form cobalt hydroxide which readily oxidizes in the presence of air to the oxide. The hydroxide and the oxide form a gelatinous precipitate which can constitute a substantial cobalt loss in the process. This EDTA-solution step of the process is conducted advantageously at about 68° C.

Workup

  1. customA solution of tetrasodium ethylenediaminetetraacetate was prepared

Sources & evidence

ORD record
ord-df711ee5b7414c32abfeec3181e7fff8
Source dataset
uspto-grants-1983_07
Patent number
US04394355

Reaction notes

Loading…