Acetic Acid → 8-Aminodibenzo[b,f]thiepin-3-carboxylic Acid Hydrochloride Salt

HRID 1075003Notes

Reaction equation

HRID 1075003 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[S:11][C:10]3[CH:12]=C(C#N)[CH:14]=[CH:15][C:9]=3[CH:8]=[CH:7][C:6]=2[CH:18]=1.[ClH:19].[C:20]([OH:23])(=[O:22])[CH3:21]>>[ClH:19].[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[S:11][C:10]3[CH:12]=[C:21]([C:20]([OH:23])=[O:22])[CH:14]=[CH:15][C:9]=3[CH:8]=[CH:7][C:6]=2[CH:18]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 131518838-Amino-3-cyanodibenzo[b,f]thiepin

Product 1

HCID 131518868-Aminodibenzo[b,f]thiepin-3-carboxylic Acid Hydrochloride Salt

Procedure

850 Mg. 8-amino-3-cyanodibenzo[b,f]-thiepin is refluxed in a mixture of 20 cc. acetic acid and 20 cc. concentrated hydrochloric acid for 48 hours. The suspended solid is filtered, washed with some acetic acid, dried overnight under vacuum at 70° C. to yield 600 mg. pure compound, m.p. 308°-311° C.

Workup

  1. filtrationThe suspended solid is filtered
  2. washwashed with some acetic acid
  3. customdried overnight under vacuum at 70° C.
  4. customto yield 600 mg

Sources & evidence

ORD record
ord-87a8b10d034c4effae03c97243c04fde
Source dataset
uspto-grants-1983_07
Patent number
US04394515

Reaction notes

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