HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 178515336, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 3-Cyanomethyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin | HCID 20270230 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178515336 | HCID 178515336 | — |
Reaction Steps
Add to 25 cc. of tetrahydrofuran cooled in an ice bath 1.59 gm. (11.9 mmole) of aluminum chloride, 1.33 gm. (5.25 mmole) of 3-cyanomethyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin and 1.55 gm. (23.8 mmole) of sodium azide. Reflux the mixture for 19 hours, cool, dilute with water and acidify. Extract the mixture into ethyl acetate and evaporate. Triturate the residue in ether and separate the title product by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04394515 |
| Source dataset | uspto-grants-1983_07 |
| ORD ID | ord-75ae7bdc15cd4bd8b5ef778be119a9a4 |
| Source note | uspto-grants-1983_07 |