反应详情

Add to 25 cc. of tetrahydrofuran cooled in an ice bath 1.59 gm. (11.9 mmole) of aluminum chloride, 1.33 gm. (5.25 mmole) of 3-cyanomethyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin and 1.55 gm. (23.8 mmole) of sodium azide. Reflux the mixture for 19 hours, cool, dilute with water and acidify. Extract the mixture into ethyl acetate and evaporate. Triturate the residue in ether and separate the title product by filtration.

1. additionAdd to 25 cc
2. temperatureReflux the mixture for 19 hours
3. temperaturecool
4. extractionExtract the mixture into ethyl acetate
5. customevaporate
6. customTriturate the residue in ether
7. customseparate the title product
8. filtrationby filtration